Abstract Detail

Abstract

The scientific world believes that microbial correction of microbiota in patients with tuberculosis of bones and joints is important not only for studying the state of health. Now scientists are sure that microbes are important for the treatment of diseases. How can intestinal microbiota dysbacteriosis modulate the body's susceptibility to Mycobacterium tuberculosis? The main material of the study was 100 patients, of which 60 (60.0%) patients with complicated tuberculous spondylitis made up group 1; 40 (40.0%) patients with non- specific spondylitis formed group 2. The examined patients were determined to have disorders of the motor function of the gastrointestinal tract in complicated tuberculous spondylitis in dysfunction of the spinal cord, i.e. in the pre- and postoperative period, localization of the tuberculous process in the segment of the spine affected by tuberculosis, risk factors for variants of disorders of the motor function of the gastrointestinal tract. The majority were people of working age from 21 to 60 years old - 64.1% (n = 59). The average age was 37.2 1.2 years. Of the examined patients, men; In group 1 there were 32 (53.3%) people; in group 2 - 22 (55.0%) people; women; in group 1 - 28 (52.1%) people; in group 2 -18 (47.8%) people. Objectives. To summarize the results of studies of the intestinal microbiome in patients with tuberculosis of bones and joints. Taxonomic diversity indices indicated differences in the structure of microbial communities of healthy bones and joints and patients with tuberculosis. The composition of the microbiota of healthy bones and joints differed in taxonomic diversity and was represented by gram-positive and gram-negative bacteria with fairly close metabolic potential. The microbiota of bones and joints examined for tuberculosis consisted of 99.9% Mycobacterium tuberculosis. Microbiota in extrapulmonary tuberculosis Variability of microbiota in extrapulmonary tuberculosis. In the prevention of extrapulmonary tuberculosis in patients with microbiota disorders. The audience will be able to use in practical work. Infectious disease faculty can use this study to expand their research or teaching. A practical solution to a problem in the prevention and early diagnosis of extrapulmonary tuberculosis.

Biography

Tuychiev Nuriddin Nazarovich, received a doctorate in medicine from the Republican Specialized Scientific and Practical Medical Center of Phthisiology and Pulmonology named after Academician Sh. Alimov in 2024 and a bachelor's degree in medicine from Tashkent Medical University. Received a certificate in clinical use of blood components and products in 2024. International Classification of Medical Interventions and Rules for Registration of Medical Documents in 2024. Orthopedist for infectious diseases. Head of the Department of Clinical Medicine and Head of 35 medical workers of the infectious diseases hospital, November 2017 - present. Clinical Medicine of Infectious Diseases for Patients November 2008-2017y. Since 2025, I have been working on the scientific topic "Pathogenesis of genetic variability of intestinal microbiota in osteoarticular tuberculosis. I have 7 scientific papers on bone and joint tuberculosis. Central Asian Jurnal of Medicine № 3/2022.Р.-115-120 European Science Review. Austria, Vienna №7-8., 2015. July-August P.-113-115 Journal Bulletin of Doctors of Uzbekistan. Tashkent 2015. - No. 4. - P. 88-90. TMA Bulletin Tashkent, 2014. - No. 4. - P. 149-151.